Publications

2021

Alexander KA, Coté A, Nguyen SC, Zhang L, Gholamalamdari O, Agudelo-Garcia P, Lin-Shiao E, Tanim KMA, Lim J, Biddle N, Dunagin MC, Good CR, Mendoza MR, Little SC, Belmont A, Joyce EF, Raj A, Berger SL. p53 mediates target gene association with nuclear speckles for amplified RNA expression. Mol Cell. 2021 Apr 15;81(8):1666-1681.e6. doi: 10.1016/j.molcel.2021.03.006. Epub 2021 Apr 5. PMID: 33823140.

Luense LJ, Berger SL. RNA modification to the rescue! Cell Host Microbe. 2021 Mar 10;29(3):313-315. doi: 10.1016/j.chom.2021.02.015. PMID: 33705698.

Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, Greenplate AR, Hakeem MA, Chen Q, Kurachi M, Nzingha K, Ekshyyan V, Mathew D, Wen Z, Speck NA, Battle A, Berger SL, Wherry EJ, Shi J.In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer. Cell. 2021 Mar 4;184(5):1262-1280.e22. doi: 10.1016/j.cell.2021.02.019. Epub 2021 Feb 25. PMID: 33636129.

Wang L, Xu C, Johansen T, Berger SL, Dou Z. SIRT1 – a new mammalian substrate of nuclear autophagy. Autophagy. 2021 Feb;17(2):593-595. doi: 10.1080/15548627.2020.1860541. Epub 2020 Dec 20. PMID: 33292048.

Grant PA, Winston F, Berger SL. The biochemical and genetic discovery of the SAGA complex. Biochim Biophys Acta Gene Regul Mech. 2021 Feb;1864(2):194669. doi: 10.1016/j.bbagrm.2020.194669. Epub 2020 Dec 16. PMID: 33338653 Review.

Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PMID: 34358447.

Capell BC and Berger SL. (2021) The role of epigenetics in disease and treatment. Chapter in:  Harrison’s Principles of Internal Medicine, 20th  Editors: Kasper D, Fauci A, Hauser S, Longo D, Jameson JL and Loscalzo J.

2020

Grant PA, Winston F, Berger SL. The biochemical and genetic discovery of theSAGA complex. Biochim Biophys Acta Gene Regul Mech. 2021 Feb;1864(2):194669.doi: 10.1016/j.bbagrm.2020.194669. Epub 2020 Dec 16. PMID: 33338653; PMCID:PMC7854503.

Wang L, Xu C, Johansen T, Berger SL, Dou Z. SIRT1 – a new mammalian substrateof nuclear autophagy. Autophagy. 2021 Feb;17(2):593-595. doi:10.1080/15548627.2020.1860541. Epub 2020 Dec 20. PMID: 33292048; PMCID:PMC8007159.

Egervari G, Glastad KM, Berger SL. Food for thought. Science. 2020 Nov6;370(6517):660-662. doi: 10.1126/science.abb4367. PMID: 33154125; PMCID:PMC7951802.

Nativio R, Lan Y, Donahue G, Sidoli S, Berson A, Srinivasan AR, ShcherbakovaO, Amlie-Wolf A, Nie J, Cui X, He C, Wang LS, Garcia BA, Trojanowski JQ, BoniniNM, Berger SL. Author Correction: An integrated multi-omics approach identifiesepigenetic alterations associated with Alzheimer’s disease. Nat Genet. 2020Nov;52(11):1266. doi: 10.1038/s41588-020-00733-7. Erratum for: Nat Genet. 2020Oct;52(10):1024-1035. PMID: 33033384.

Nativio R, Lan Y, Donahue G, Sidoli S, Berson A, Srinivasan AR, ShcherbakovaO, Amlie-Wolf A, Nie J, Cui X, He C, Wang LS, Garcia BA, Trojanowski JQ, BoniniNM, Berger SL. An integrated multi-omics approach identifies epigeneticalterations associated with Alzheimer’s disease. Nat Genet. 2020Oct;52(10):1024-1035. doi: 10.1038/s41588-020-0696-0. Epub 2020 Sep 28. Erratumin: Nat Genet. 2020 Nov;52(11):1266. PMID: 32989324; PMCID: PMC8098004.

Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, BretzC, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, DouZ, Berger SL. SIRT1 is downregulated by autophagy in senescence and ageing. NatCell Biol. 2020 Oct;22(10):1170-1179. doi: 10.1038/s41556-020-00579-5. Epub 2020Sep 28. PMID: 32989246; PMCID: PMC7805578.

Crespo M, Luense LJ, Arlotto M, Hu J, Dorsey J, García-Oliver E, Shah PP,Pflieger D, Berger SL, Govin J. Systematic genetic and proteomic screens duringgametogenesis identify H2BK34 methylation as an evolutionary conserved meioticmark. Epigenetics Chromatin. 2020 Sep 15;13(1):35. doi:10.1186/s13072-020-00349-5. PMID: 32933557; PMCID: PMC7493871.

Sheng L, Shields EJ, Gospocic J, Glastad KM, Ratchasanmuang P, Berger SL,Raj A, Little S, Bonasio R. Social reprogramming in ants induces longevity-associated glia remodeling. Sci Adv. 2020 Aug 19;6(34):eaba9869. doi:10.1126/sciadv.aba9869. PMID: 32875108; PMCID: PMC7438095.

Agudelo Garcia PA, Berger SL. Genetics Meets Epigenetics in Treg Cells andAutoimmunity. Immunity. 2020 Jun 16;52(6):897-899. doi:10.1016/j.immuni.2020.05.009. PMID: 32553177; PMCID: PMC7751621.

Yang F, Lan Y, Pandey RR, Homolka D, Berger SL, Pillai RS, Bartolomei MS,Wang PJ. TEX15 associates with MILI and silences transposable elements in malegerm cells. Genes Dev. 2020 Jun 1;34(11-12):745-750. doi:10.1101/gad.335489.119. Epub 2020 May 7. PMID: 32381626; PMCID: PMC7263141.

Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM,Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL,Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S, Ruella M.Impaired Death Receptor Signaling in Leukemia Causes Antigen-IndependentResistance by Inducing CAR T-cell Dysfunction. Cancer Discov. 2020Apr;10(4):552-567. doi: 10.1158/2159-8290.CD-19-0813. Epub 2020 Jan 30. PMID:32001516; PMCID: PMC7416790.

Vizioli MG, Liu T, Miller KN, Robertson NA, Gilroy K, Lagnado AB, Perez-Garcia A, Kiourtis C, Dasgupta N, Lei X, Kruger PJ, Nixon C, Clark W, Jurk D,Bird TG, Passos JF, Berger SL, Dou Z, Adams PD. Mitochondria-to-nucleusretrograde signaling drives formation of cytoplasmic chromatin and inflammationin senescence. Genes Dev. 2020 Mar 1;34(5-6):428-445. doi:10.1101/gad.331272.119. Epub 2020 Jan 30. PMID: 32001510; PMCID: PMC7050483.

Luense LJ, Donahue G, Lin-Shiao E, Rangel R, Weller AH, Bartolomei MS,Berger SL. Gcn5-Mediated Histone Acetylation Governs Nucleosome Dynamics inSpermiogenesis. Dev Cell. 2019 Dec 16;51(6):745-758.e6. doi:10.1016/j.devcel.2019.10.024. Epub 2019 Nov 21. PMID: 31761669; PMCID:PMC6917834.

Glastad KM, Graham RJ, Ju L, Roessler J, Brady CM, Berger SL. EpigeneticRegulator CoREST Controls Social Behavior in Ants. Mol Cell. 2020 Jan16;77(2):338-351.e6. doi: 10.1016/j.molcel.2019.10.012. Epub 2019 Nov 12. PMID:31732456; PMCID: PMC7444844.

2019

Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, AlexanderDC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL. Alcohol metabolismcontributes to brain histone acetylation. Nature. 2019 Oct;574(7780):717-721.doi: 10.1038/s41586-019-1700-7. Epub 2019 Oct 23. PMID: 31645761; PMCID:PMC6907081.

Chen Z, Ji Z, Ngiow SF, Manne S, Cai Z, Huang AC, Johnson J, Staupe RP,Bengsch B, Xu C, Yu S, Kurachi M, Herati RS, Vella LA, Baxter AE, Wu JE, Khan O,Beltra JC, Giles JR, Stelekati E, McLane LM, Lau CW, Yang X, Berger SL, VahediG, Ji H, Wherry EJ. TCF-1-Centered Transcriptional Network Drives an Effectorversus Exhausted CD8 T Cell-Fate Decision. Immunity. 2019 Nov19;51(5):840-855.e5. doi: 10.1016/j.immuni.2019.09.013. Epub 2019 Oct 9. PMID:31606264; PMCID: PMC6943829.

Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, HuangAC, Alexander KA, Wu JE, Attanasio J, Yan P, George SM, Bengsch B, Staupe RP,Donahue G, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM,Kaye J, Berger SL, Wherry EJ. TOX transcriptionally and epigenetically programsCD8+ T cell exhaustion. Nature. 2019 Jul;571(7764):211-218. doi:10.1038/s41586-019-1325-x. Epub 2019 Jun 17. PMID: 31207603; PMCID: PMC6713202.

Lin-Shiao E, Lan Y, Welzenbach J, Alexander KA, Zhang Z, Knapp M, Mangold E,Sammons M, Ludwig KU, Berger SL. p63 establishes epithelial enhancers atcritical craniofacial development genes. Sci Adv. 2019 May 1;5(5):eaaw0946. doi:10.1126/sciadv.aaw0946. PMID: 31049400; PMCID: PMC6494499.

Catizone AN, Good CR, Alexander KA, Berger SL, Sammons MA. Comparison ofgenotoxic versus nongenotoxic stabilization of p53 provides insight intoparallel stress-responsive transcriptional networks. Cell Cycle. 2019Apr;18(8):809-823. doi: 10.1080/15384101.2019.1593643. Epub 2019 Apr 9. PMID:30966857; PMCID: PMC6527265.

Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, LuenseLJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. HistoneAcetyltransferase p300 Induces De Novo Super-Enhancers to Drive CellularSenescence. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi:10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. PMID: 30773298; PMCID:PMC6688479.

Schon SB, Luense LJ, Wang X, Bartolomei MS, Coutifaris C, Garcia BA, BergerSL. Histone modification signatures in human sperm distinguish clinicalabnormalities. J Assist Reprod Genet. 2019 Feb;36(2):267-275. doi:10.1007/s10815-018-1354-7. Epub 2018 Nov 5. PMID: 30397898; PMCID: PMC6420512.

2018

Ghaninia M, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J. AntennalOlfactory Physiology and Behavior of Males of the Ponerine Ant Harpegnathossaltator. J Chem Ecol. 2018 Nov;44(11):999-1007. doi: 10.1007/s10886-018-1013-6.Epub 2018 Sep 7. PMID: 30191433; PMCID: PMC7202683.

Li X, Egervari G, Wang Y, Berger SL, Lu Z. Regulation of chromatin and geneexpression by metabolic enzymes and metabolites. Nat Rev Mol Cell Biol. 2018Sep;19(9):563-578. doi: 10.1038/s41580-018-0029-7. PMID: 29930302; PMCID:PMC6907087.

Berson A, Nativio R, Berger SL, Bonini NM. Epigenetic Regulation inNeurodegenerative Diseases. Trends Neurosci. 2018 Sep;41(9):587-598. doi:10.1016/j.tins.2018.05.005. Epub 2018 Jun 7. PMID: 29885742; PMCID: PMC6174532.

Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP,Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I,Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH,Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL,Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, BushmanFD, June CH, Melenhorst JJ. Disruption of TET2 promotes the therapeutic efficacyof CD19-targeted T cells. Nature. 2018 Jun;558(7709):307-312. doi:10.1038/s41586-018-0178-z. Epub 2018 May 30. PMID: 29849141; PMCID: PMC6320248.

Lee JV, Berry CT, Kim K, Sen P, Kim T, Carrer A, Trefely S, Zhao S,Fernandez S, Barney LE, Schwartz AD, Peyton SR, Snyder NW, Berger SL, FreedmanBD, Wellen KE. Acetyl-CoA promotes glioblastoma cell adhesion and migrationthrough Ca2+-NFAT signaling. Genes Dev. 2018 Apr 1;32(7-8):497-511.doi: 10.1101/gad.311027.117. Epub 2018 Apr 19. PMID: 29674394; PMCID:PMC5959234.

Dou Z, Berger SL. Senescence Elicits Stemness: A Surprising Mechanism forCancer Relapse. Cell Metab. 2018 Apr 3;27(4):710-711. doi:10.1016/j.cmet.2018.03.009. PMID: 29617638; PMCID: PMC7205594.

Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB,Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM,Berger SL. Publisher Correction: Dysregulation of the epigenetic landscape ofnormal aging in Alzheimer’s disease. Nat Neurosci. 2018 Jul;21(7):1018. doi:10.1038/s41593-018-0124-2. Erratum for: Nat Neurosci. 2018 Apr;21(4):497-505.PMID: 29556027.

Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB,Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM,Berger SL. Dysregulation of the epigenetic landscape of normal aging inAlzheimer’s disease. Nat Neurosci. 2018 Apr;21(4):497-505. doi:10.1038/s41593-018-0101-9. Epub 2018 Mar 5. Erratum in: Nat Neurosci. 2018 Mar19;: PMID: 29507413; PMCID: PMC6124498.

Lin-Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson CL, Sen P,Saffie R, Busino L, Garcia BA, Berger SL, Capell BC. KMT2D regulates p63 targetenhancers to coordinate epithelial homeostasis. Genes Dev. 2018 Jan15;32(2):181-193. doi: 10.1101/gad.306241.117. Epub 2018 Feb 12. PMID: 29440247;PMCID: PMC5830930.

Berger SL, Leo-Macias A, Yuen S, Khatri L, Pfennig S, Zhang Y, Agullo-Pascual E, Caillol G, Zhu MS, Rothenberg E, Melendez-Vasquez CV, Delmar M,Leterrier C, Salzer JL. Localized Myosin II Activity Regulates Assembly andPlasticity of the Axon Initial Segment. Neuron. 2018 Feb 7;97(3):555-570.e6.doi: 10.1016/j.neuron.2017.12.039. Epub 2018 Jan 25. PMID: 29395909; PMCID:PMC5805619.

Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA,Gilbert LA, Weissman JS, Berger SL, Kaestner KH. Combinatorial genetics in liverrepopulation and carcinogenesis with a in vivo CRISPR activation platform.Hepatology. 2018 Aug;68(2):663-676. doi: 10.1002/hep.29626. Epub 2018 May 14.PMID: 29091290; PMCID: PMC5930141.

2017

Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S,Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM.TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Curr Biol.2017 Dec 4;27(23):3579-3590.e6. doi: 10.1016/j.cub.2017.10.024. Epub 2017 Nov16. PMID: 29153328; PMCID: PMC5720388.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y,Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-CarmelM, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, AdamsPD, Berger SL. Cytoplasmic chromatin triggers inflammation in senescence andcancer. Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub2017 Oct 4. PMID: 28976970; PMCID: PMC5850938.

Bose DA, Berger SL. eRNA binding produces tailored CBP activity profiles toregulate gene expression. RNA Biol. 2017 Dec 2;14(12):1655-1659. doi:10.1080/15476286.2017.1353862. Epub 2017 Sep 26. PMID: 28891741; PMCID:PMC5731803.

Pask GM, Slone JD, Millar JG, Das P, Moreira JA, Zhou X, Bello J, Berger SL,Bonasio R, Desplan C, Reinberg D, Liebig J, Zwiebel LJ, Ray A. Specializedodorant receptors in social insects that detect cuticular hydrocarbon cues andcandidate pheromones. Nat Commun. 2017 Aug 17;8(1):297. doi:10.1038/s41467-017-00099-1. PMID: 28819196; PMCID: PMC5561057.

Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS,Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R. TheNeuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants.Cell. 2017 Aug 10;170(4):748-759.e12. doi: 10.1016/j.cell.2017.07.014. PMID:28802044; PMCID: PMC5564227.

Yan H, Opachaloemphan C, Mancini G, Yang H, Gallitto M, Mlejnek J, LeibholzA, Haight K, Ghaninia M, Huo L, Perry M, Slone J, Zhou X, Traficante M, PenickCA, Dolezal K, Gokhale K, Stevens K, Fetter-Pruneda I, Bonasio R, Zwiebel LJ,Berger SL, Liebig J, Reinberg D, Desplan C. An Engineered orco Mutation ProducesAberrant Social Behavior and Defective Neural Development in Ants. Cell. 2017Aug 10;170(4):736-747.e9. doi: 10.1016/j.cell.2017.06.051. PMID: 28802043;PMCID: PMC5587193.

Levine AJ, Berger SL. The interplay between epigenetic changes and the p53protein in stem cells. Genes Dev. 2017 Jun 15;31(12):1195-1201. doi:10.1101/gad.298984.117. PMID: 28765161; PMCID: PMC5558922.

Slone JD, Pask GM, Ferguson ST, Millar JG, Berger SL, Reinberg D, Liebig J,Ray A, Zwiebel LJ. Functional characterization of odorant receptors in theponerine ant, Harpegnathos saltator. Proc Natl Acad Sci U S A. 2017 Aug8;114(32):8586-8591. doi: 10.1073/pnas.1704647114. Epub 2017 Jul 10. PMID:28696298; PMCID: PMC5559025.

Ghaninia M, Haight K, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J.Chemosensory sensitivity reflects reproductive status in the ant Harpegnathossaltator. Sci Rep. 2017 Jun 16;7(1):3732. doi: 10.1038/s41598-017-03964-7. PMID:28623371; PMCID: PMC5473913.

Mews P, Donahue G, Drake AM, Luczak V, Abel T, Berger SL. Acetyl-CoAsynthetase regulates histone acetylation and hippocampal memory. Nature. 2017Jun 15;546(7658):381-386. doi: 10.1038/nature22405. Epub 2017 May 31. PMID:28562591; PMCID: PMC5505514.

Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL. RNABinding to CBP Stimulates Histone Acetylation and Transcription. Cell. 2017 Jan12;168(1-2):135-149.e22. doi: 10.1016/j.cell.2016.12.020. Epub 2017 Jan 12.PMID: 28086087; PMCID: PMC5325706.

Bonini NM, Berger SL. The Sustained Impact of Model Organisms-in Geneticsand Epigenetics. Genetics. 2017 Jan;205(1):1-4. doi:10.1534/genetics.116.187864. PMID: 28049700; PMCID: PMC5223495.

2016

Berger SL, Sassone-Corsi P. Metabolic Signaling to Chromatin. Cold SpringHarb Perspect Biol. 2016 Nov 1;8(11):a019463. doi: 10.1101/cshperspect.a019463.PMID: 26492570; PMCID: PMC5088527.

Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, ChenZ, Sen DR, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM,Vahedi G, Haining WN, Berger SL, Wherry EJ. Epigenetic stability of exhausted Tcells limits durability of reinvigoration by PD-1 blockade. Science. 2016 Dec2;354(6316):1160-1165. doi: 10.1126/science.aaf2807. Epub 2016 Oct 27. PMID:27789795; PMCID: PMC5484795.

Crowe EP, Tuzer F, Gregory BD, Donahue G, Gosai SJ, Cohen J, Leung YY,Yetkin E, Nativio R, Wang LS, Sell C, Bonini NM, Berger SL, Johnson FB, TorresC. Changes in the Transcriptome of Human Astrocytes Accompanying OxidativeStress-Induced Senescence. Front Aging Neurosci. 2016 Aug 31;8:208. doi:10.3389/fnagi.2016.00208. PMID: 27630559; PMCID: PMC5005348.

Hur SK, Freschi A, Ideraabdullah F, Thorvaldsen JL, Luense LJ, Weller AH,Berger SL, Cerrato F, Riccio A, Bartolomei MS. Humanized H19/Igf2 locus revealsdiverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes. Proc Natl Acad Sci U S A. 2016 Sep27;113(39):10938-43. doi: 10.1073/pnas.1603066113. Epub 2016 Sep 12. PMID:27621468; PMCID: PMC5047210.

Zhu J, Dou Z, Sammons MA, Levine AJ, Berger SL. Lysine methylation repressesp53 activity in teratocarcinoma cancer cells. Proc Natl Acad Sci U S A. 2016 Aug30;113(35):9822-7. doi: 10.1073/pnas.1610387113. Epub 2016 Aug 17. PMID:27535933; PMCID: PMC5024588.

Sen P, Shah PP, Nativio R, Berger SL. Epigenetic Mechanisms of Longevity andAging. Cell. 2016 Aug 11;166(4):822-839. doi: 10.1016/j.cell.2016.07.050. PMID:27518561; PMCID: PMC5821249.

Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT,Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL,Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM,Berger SL, Adams PD. Mapping H4K20me3 onto the chromatin landscape of senescentcells indicates a function in control of cell senescence and tumor suppressionthrough preservation of genetic and epigenetic stability. Genome Biol. 2016 Jul25;17(1):158. doi: 10.1186/s13059-016-1017-x. PMID: 27457071; PMCID: PMC4960804.

Mews P, Berger SL. Exploring the Dynamic Relationship Between CellularMetabolism and Chromatin Structure Using SILAC-Mass Spec and ChIP-Sequencing.Methods Enzymol. 2016;574:311-329. doi: 10.1016/bs.mie.2016.04.002. Epub 2016May 31. PMID: 27423866.

Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-SilvermanL, Manfredi JJ, Berger SL, McMahon SB. A rare DNA contact mutation in cancerconfers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. MolOncol. 2016 Oct;10(8):1207-20. doi: 10.1016/j.molonc.2016.05.007. Epub 2016 Jun7. PMID: 27341992; PMCID: PMC5423199.

Sammons MA, Zhu J, Berger SL. A Chromatin-Focused siRNA Screen forRegulators of p53-Dependent Transcription. G3 (Bethesda). 2016 Aug9;6(8):2671-8. doi: 10.1534/g3.116.031534. PMID: 27334938; PMCID: PMC4978920.

Luense LJ, Wang X, Schon SB, Weller AH, Lin Shiao E, Bryant JM, BartolomeiMS, Coutifaris C, Garcia BA, Berger SL. Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells. EpigeneticsChromatin. 2016 Jun 21;9:24. doi: 10.1186/s13072-016-0072-6. PMID: 27330565;PMCID: PMC4915177.

Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G,Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL. MLL1 is essentialfor the senescence-associated secretory phenotype. Genes Dev. 2016 Feb1;30(3):321-36. doi: 10.1101/gad.271882.115. PMID: 26833731; PMCID: PMC4743061.

Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ,Bonasio R, Reinberg D, Liebig J, Berger SL. Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus. Science. 2016 Jan1;351(6268):aac6633. doi: 10.1126/science.aac6633. PMID: 26722000; PMCID:PMC5057185.

2015

Dou Z, Ivanov A, Adams PD, Berger SL. Mammalian autophagy degrades nuclearconstituents in response to tumorigenic stress. Autophagy. 2016 Aug2;12(8):1416-7. doi: 10.1080/15548627.2015.1127465. Epub 2015 Dec 10. PMID:26654219; PMCID: PMC4968220.

Hu J, Donahue G, Dorsey J, Govin J, Yuan Z, Garcia BA, Shah PP, Berger SL.H4K44 Acetylation Facilitates Chromatin Accessibility during Meiosis. Cell Rep.2015 Dec 1;13(9):1772-80. doi: 10.1016/j.celrep.2015.10.070. Epub 2015 Nov 25.PMID: 26628362; PMCID: PMC4793274.

Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, DrakeAM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, ZongWX, Johansen T, Goldman RD, Adams PD, Berger SL. Autophagy mediates degradationof nuclear lamina. Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548.Epub 2015 Oct 28. PMID: 26524528; PMCID: PMC4824414.

Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D,Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL.Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.Nature. 2015 Sep 10;525(7568):206-11. doi: 10.1038/nature15251. Epub 2015 Sep 2.PMID: 26331536; PMCID: PMC4568559.

Dikovskaya D, Cole JJ, Mason SM, Nixon C, Karim SA, McGarry L, Clark W,Hewitt RN, Sammons MA, Zhu J, Athineos D, Leach JD, Marchesi F, van Tuyn J, TaitSW, Brock C, Morton JP, Wu H, Berger SL, Blyth K, Adams PD. Mitotic Stress Is anIntegral Part of the Oncogene-Induced Senescence Program that PromotesMultinucleation and Cell Cycle Arrest. Cell Rep. 2015 Sep 1;12(9):1483-96. doi:10.1016/j.celrep.2015.07.055. Epub 2015 Aug 20. PMID: 26299965; PMCID:PMC4562906.

Sharma KR, Enzmann BL, Schmidt Y, Moore D, Jones GR, Parker J, Berger SL,Reinberg D, Zwiebel LJ, Breit B, Liebig J, Ray A. Cuticular HydrocarbonPheromones for Social Behavior and Their Coding in the Ant Antenna. Cell Rep.2015 Aug 25;12(8):1261-71. doi: 10.1016/j.celrep.2015.07.031. Epub 2015 Aug 13.PMID: 26279569.

Zhou X, Rokas A, Berger SL, Liebig J, Ray A, Zwiebel LJ. ChemoreceptorEvolution in Hymenoptera and Its Implications for the Evolution of Eusociality.Genome Biol Evol. 2015 Aug 12;7(8):2407-16. doi: 10.1093/gbe/evv149. PMID:26272716; PMCID: PMC4558866.

McNeal AS, Liu K, Nakhate V, Natale CA, Duperret EK, Capell BC, Dentchev T,Berger SL, Herlyn M, Seykora JT, Ridky TW. CDKN2B Loss Promotes Progression fromBenign Melanocytic Nevus to Melanoma. Cancer Discov. 2015 Oct;5(10):1072-85.doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16. PMID: 26183406; PMCID:PMC4592422.

Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, LeeJY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M,Kennedy BK, Boeke JD, Berger SL. H3K36 methylation promotes longevity byenhancing transcriptional fidelity. Genes Dev. 2015 Jul 1;29(13):1362-76. doi:10.1101/gad.263707.115. PMID: 26159996; PMCID: PMC4511212.

Bryant JM, Donahue G, Wang X, Meyer-Ficca M, Luense LJ, Weller AH,Bartolomei MS, Blobel GA, Meyer RG, Garcia BA, Berger SL. Characterization ofBRD4 during mammalian postmeiotic sperm development. Mol Cell Biol. 2015Apr;35(8):1433-48. doi: 10.1128/MCB.01328-14. Epub 2015 Feb 17. PMID: 25691659;PMCID: PMC4372693.

2014

Butin-Israeli V, Adam SA, Jain N, Otte GL, Neems D, Wiesmüller L, Berger SL,Goldman RD. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015Mar;35(5):884-98. doi: 10.1128/MCB.01145-14. Epub 2014 Dec 22. PMID: 25535332;PMCID: PMC4323489.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, FranceschiC, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 2014 Nov6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039. PMID: 25417146; PMCID:PMC4852871.

Sammons MA, Zhu J, Drake AM, Berger SL. TP53 engagement with the genomeoccurs in distinct local chromatin environments via pioneer factor activity.Genome Res. 2015 Feb;25(2):179-88. doi: 10.1101/gr.181883.114. Epub 2014 Nov 12.PMID: 25391375; PMCID: PMC4315292.

Qin J, Rajaratnam R, Feng L, Salami J, Barber-Rotenberg JS, Domsic J, Reyes-Uribe P, Liu H, Dang W, Berger SL, Villanueva J, Meggers E, Marmorstein R.Development of organometallic S6K1 inhibitors. J Med Chem. 2015 Jan8;58(1):305-14. doi: 10.1021/jm5011868. Epub 2014 Nov 13. PMID: 25356520; PMCID:PMC4289024.

Yan H, Bonasio R, Simola DF, Liebig J, Berger SL, Reinberg D. DNAmethylation in social insects: how epigenetics can control behavior andlongevity. Annu Rev Entomol. 2015 Jan 7;60:435-52. doi: 10.1146/annurev-ento-010814-020803. Epub 2014 Oct 17. PMID: 25341091.

Yan H, Simola DF, Bonasio R, Liebig J, Berger SL, Reinberg D. Eusocialinsects as emerging models for behavioural epigenetics. Nat Rev Genet. 2014Oct;15(10):677-88. doi: 10.1038/nrg3787. Epub 2014 Sep 9. PMID: 25200663.

Mews P, Zee BM, Liu S, Donahue G, Garcia BA, Berger SL. Histone methylationhas dynamics distinct from those of histone acetylation in cell cycle reentryfrom quiescence. Mol Cell Biol. 2014 Nov;34(21):3968-80. doi:10.1128/MCB.00763-14. Epub 2014 Aug 25. PMID: 25154414; PMCID: PMC4386454.

McCormick MA, Mason AG, Guyenet SJ, Dang W, Garza RM, Ting MK, Moller RM,Berger SL, Kaeberlein M, Pillus L, La Spada AR, Kennedy BK. The SAGA histonedeubiquitinase module controls yeast replicative lifespan via Sir2 interaction.Cell Rep. 2014 Jul 24;8(2):477-86. doi: 10.1016/j.celrep.2014.06.037. Epub 2014Jul 18. PMID: 25043177; PMCID: PMC4284099.

Lin S, Wein S, Gonzales-Cope M, Otte GL, Yuan ZF, Afjehi-Sadat L, Maile T,Berger SL, Rush J, Lill JR, Arnott D, Garcia BA. Stable-isotope-labeled histonepeptide library for histone post-translational modification and variantquantification by mass spectrometry. Mol Cell Proteomics. 2014Sep;13(9):2450-66. doi: 10.1074/mcp.O113.036459. Epub 2014 Jul 7. PMID:25000943; PMCID: PMC4159661.

Brunet A, Berger SL. Epigenetics of aging and aging-related disease. JGerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1(Suppl 1):S17-20. doi:10.1093/gerona/glu042. PMID: 24833581; PMCID: PMC4022130.

Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, SaviolakiD, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R,Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Inactivation of yeast Isw2chromatin remodeling enzyme mimics longevity effect of calorie restriction viainduction of genotoxic stress response. Cell Metab. 2014 Jun 3;19(6):952-66.doi: 10.1016/j.cmet.2014.04.004. Epub 2014 May 8. PMID: 24814484; PMCID:PMC4106248.

2013

Cruickshanks HA, McBryan T, Nelson DM, Vanderkraats ND, Shah PP, van Tuyn J,Singh Rai T, Brock C, Donahue G, Dunican DS, Drotar ME, Meehan RR, Edwards JR,Berger SL, Adams PD. Senescent cells harbour features of the cancer epigenome.Nat Cell Biol. 2013 Dec;15(12):1495-506. doi: 10.1038/ncb2879. Epub 2013 Nov 24.PMID: 24270890; PMCID: PMC4106249.

Bryant JM, Meyer-Ficca ML, Dang VM, Berger SL, Meyer RG. Separation ofspermatogenic cell types using STA-PUT velocity sedimentation. J Vis Exp. 2013Oct 9;(80):50648. doi: 10.3791/50648. PMID: 24145866; PMCID: PMC3939054.

Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V,Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD, Berger SL. Lamin B1depletion in senescent cells triggers large-scale changes in gene expression andthe chromatin landscape. Genes Dev. 2013 Aug 15;27(16):1787-99. doi:10.1101/gad.223834.113. Epub 2013 Aug 9. PMID: 23934658; PMCID: PMC3759695.

Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, ShahPP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD. Lysosome-mediated processing of chromatin in senescence. J Cell Biol. 2013 Jul8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1. PMID: 23816621;PMCID: PMC3704985.

Capell BC, Berger SL. Genome-wide epigenetics. J Invest Dermatol. 2013Jun;133(6):e9. doi: 10.1038/jid.2013.173. PMID: 23673507; PMCID: PMC4824393.

Simola DF, Wissler L, Donahue G, Waterhouse RM, Helmkampf M, Roux J, NygaardS, Glastad KM, Hagen DE, Viljakainen L, Reese JT, Hunt BG, Graur D, Elhaik E,Kriventseva EV, Wen J, Parker BJ, Cash E, Privman E, Childers CP, Muñoz-TorresMC, Boomsma JJ, Bornberg-Bauer E, Currie CR, Elsik CG, Suen G, Goodisman MA,Keller L, Liebig J, Rawls A, Reinberg D, Smith CD, Smith CR, Tsutsui N, Wurm Y,Zdobnov EM, Berger SL, Gadau J. Social insect genomes exhibit dramatic evolutionin gene composition and regulation while preserving regulatory features linkedto sociality. Genome Res. 2013 Aug;23(8):1235-47. doi: 10.1101/gr.155408.113.Epub 2013 May 1. PMID: 23636946; PMCID: PMC3730098.

Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, TsuchiharaK, Bungard D, Berger SL, Jones RG, Mak TW, Zaugg K. Depletion of the novelp53-target gene carnitine palmitoyltransferase 1C delays tumor growth in theneurofibromatosis type I tumor model. Cell Death Differ. 2013 Apr;20(4):659-68.doi: 10.1038/cdd.2012.168. Epub 2013 Feb 15. PMID: 23412344; PMCID: PMC3595492.

2012

Simola DF, Ye C, Mutti NS, Dolezal K, Bonasio R, Liebig J, Reinberg D,Berger SL. A chromatin link to caste identity in the carpenter ant Camponotusfloridanus. Genome Res. 2013 Mar;23(3):486-96. doi: 10.1101/gr.148361.112. Epub2012 Dec 3. PMID: 23212948; PMCID: PMC3589537.

Bryant JM, Berger SL. Low-hanging fruit: targeting Brdt in the testes. EMBOJ. 2012 Oct 3;31(19):3788-9. doi: 10.1038/emboj.2012.259. Epub 2012 Sep 7. PMID:22960636; PMCID: PMC3463854.

Zhou X, Slone JD, Rokas A, Berger SL, Liebig J, Ray A, Reinberg D, ZwiebelLJ. Phylogenetic and transcriptomic analysis of chemosensory receptors in a pairof divergent ant species reveals sex-specific signatures of odor coding. PLoSGenet. 2012;8(8):e1002930. doi: 10.1371/journal.pgen.1002930. Epub 2012 Aug 30.PMID: 22952454; PMCID: PMC3431598.

Bonasio R, Li Q, Lian J, Mutti NS, Jin L, Zhao H, Zhang P, Wen P, Xiang H,Ding Y, Jin Z, Shen SS, Wang Z, Wang W, Wang J, Berger SL, Liebig J, Zhang G,Reinberg D. Genome-wide and caste-specific DNA methylomes of the ants Camponotusfloridanus and Harpegnathos saltator. Curr Biol. 2012 Oct 9;22(19):1755-64. doi:10.1016/j.cub.2012.07.042. Epub 2012 Aug 9. PMID: 22885060; PMCID: PMC3498763.

Bryant JM, Govin J, Zhang L, Donahue G, Pugh BF, Berger SL. The linkerhistone plays a dual role during gametogenesis in Saccharomyces cerevisiae. MolCell Biol. 2012 Jul;32(14):2771-83. doi: 10.1128/MCB.00282-12. Epub 2012 May 14.PMID: 22586276; PMCID: PMC3416202.

Mallory MJ, Law MJ, Sterner DE, Berger SL, Strich R. Gcn5p-dependentacetylation induces degradation of the meiotic transcriptional repressor Ume6p.Mol Biol Cell. 2012 May;23(9):1609-17. doi: 10.1091/mbc.E11-06-0536. Epub 2012Mar 21. PMID: 22438583; PMCID: PMC3338428.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR,Khanin R, Figueroa ME, Melnick A, Wellen KE, O’Rourke DM, Berger SL, Chan TA,Levine RL, Mellinghoff IK, Thompson CB. IDH mutation impairs histonedemethylation and results in a block to cell differentiation. Nature. 2012 Feb15;483(7390):474-8. doi: 10.1038/nature10860. PMID: 22343901; PMCID: PMC3478770.

Berger SL. Transgenerational inheritance of longevity: epigenetic mysteriesabound. Cell Metab. 2012 Jan 4;15(1):6-7. doi: 10.1016/j.cmet.2011.12.012. PMID:22225870.

<h3>2011</h3>
Shieh GS, Pan CH, Wu JH, Sun YJ, Wang CC, Hsiao WC, Lin CY, Tung L, ChangTH, Fleming AB, Hillyer C, Lo YC, <strong>Berger SL</strong>, Osley MA, Kao CF. H2Bubiquitylation is part of chromatin architecture that marks exon-intronstructure in budding yeast. BMC Genomics. 2011 Dec 22;12:627. doi:10.1186/1471-2164-12-627. PMID: 22188810; PMCID: PMC3274495.

Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, HodawadekarS, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW,Thibault P, Verreault A, Johnson FB, <strong>Berger SL</strong>, Sternglanz R, McMahon SB, CôtéJ, Marmorstein R. MYST protein acetyltransferase activity requires active sitelysine autoacetylation. EMBO J. 2012 Jan 4;31(1):58-70. doi:10.1038/emboj.2011.382. Epub 2011 Oct 21. PMID: 22020126; PMCID: PMC3252582.

Edwards CR, Dang W, <strong>Berger SL</strong>. Histone H4 lysine 20 of Saccharomycescerevisiae is monomethylated and functions in subtelomeric silencing.Biochemistry. 2011 Dec 6;50(48):10473-83. doi: 10.1021/bi201120q. Epub 2011 Nov11. PMID: 21985125; PMCID: PMC3697087.

Lu JY, Lin YY, Sheu JC, Wu JT, Lee FJ, Chen Y, Lin MI, Chiang FT, Tai TY,<strong>Berger SL</strong>, Zhao Y, Tsai KS, Zhu H, Chuang LM, Boeke JD. Acetylation of yeastAMPK controls intrinsic aging independently of caloric restriction. Cell. 2011Sep 16;146(6):969-79. doi: 10.1016/j.cell.2011.07.044. Epub 2011 Sep 9. PMID:21906795; PMCID: PMC3176974.

Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, Huang P, SawyerSK, Fuerth B, Faubert B, Kalliomäki T, Elia A, Luo X, Nadeem V, Bungard D,Yalavarthi S, Growney JD, Wakeham A, Moolani Y, Silvester J, Ten AY, Bakker W,Tsuchihara K, <strong>Berger SL</strong>, Hill RP, Jones RG, Tsao M, Robinson MO, Thompson CB,Pan G, Mak TW. Carnitine palmitoyltransferase 1C promotes cell survival andtumor growth under conditions of metabolic stress. Genes Dev. 2011 May15;25(10):1041-51. doi: 10.1101/gad.1987211. PMID: 21576264; PMCID: PMC3093120.

<strong>Berger SL</strong>. Cell signaling and transcriptional regulation via histonephosphorylation. Cold Spring Harb Symp Quant Biol. 2010;75:23-6. doi:10.1101/sqb.2010.75.044. Epub 2011 Apr 5. PMID: 21467136.

Zediak VP, Wherry EJ, <strong>Berger SL</strong>. The contribution of epigenetic memory toimmunologic memory. Curr Opin Genet Dev. 2011 Apr;21(2):154-9. doi:10.1016/j.gde.2011.01.016. Epub 2011 Feb 15. PMID: 21330128.

Trujillo KM, Tyler RK, Ye C, <strong>Berger SL</strong>, Osley MA. A genetic and moleculartoolbox for analyzing histone ubiquitylation and sumoylation in yeast. Methods.2011 Jul;54(3):296-303. doi: 10.1016/j.ymeth.2011.02.003. Epub 2011 Feb 15.PMID: 21310241; PMCID: PMC3610411.

Zediak VP, Johnnidis JB, Wherry EJ, <strong>Berger SL</strong>. Cutting edge: persistentlyopen chromatin at effector gene loci in resting memory CD8+ T cells independentof transcriptional status. J Immunol. 2011 Mar 1;186(5):2705-9. doi:10.4049/jimmunol.1003741. Epub 2011 Jan 28. PMID: 21278341; PMCID: PMC3474546.

2010

Yu Y, Zeng P, Xiong J, Liu Z, Berger SL, Merlino G. Epigenetic drugs canstimulate metastasis through enhanced expression of the pro-metastatic Ezringene. PLoS One. 2010 Sep 13;5(9):e12710. doi: 10.1371/journal.pone.0012710.PMID: 20856924; PMCID: PMC2938331.

Bonasio R, Zhang G, Ye C, Mutti NS, Fang X, Qin N, Donahue G, Yang P, Li Q,Li C, Zhang P, Huang Z, Berger SL, Reinberg D, Wang J, Liebig J. Genomiccomparison of the ants Camponotus floridanus and Harpegnathos saltator. Science.2010 Aug 27;329(5995):1068-71. doi: 10.1126/science.1192428. PMID: 20798317;PMCID: PMC3772619.

Govin J, Dorsey J, Gaucher J, Rousseaux S, Khochbin S, Berger SL.Systematic screen reveals new functional dynamics of histones H3 and H4 duringgametogenesis. Genes Dev. 2010 Aug 15;24(16):1772-86. doi: 10.1101/gad.1954910.PMID: 20713519; PMCID: PMC2922505.

Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, Carling D,Thompson CB, Jones RG, Berger SL. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science. 2010 Sep3;329(5996):1201-5. doi: 10.1126/science.1191241. Epub 2010 Jul 15. PMID:20647423; PMCID: PMC3922052.

Berger SL. Keeping p53 in check: a high-stakes balancing act. Cell. 2010Jul 9;142(1):17-9. doi: 10.1016/j.cell.2010.06.026. PMID: 20603009; PMCID:PMC3922053.

Govin J, Schug J, Krishnamoorthy T, Dorsey J, Khochbin S, Berger SL.Genome-wide mapping of histone H4 serine-1 phosphorylation during sporulation inSaccharomyces cerevisiae. Nucleic Acids Res. 2010 Aug;38(14):4599-606. doi:10.1093/nar/gkq218. Epub 2010 Apr 7. PMID: 20375100; PMCID: PMC2919718.

Placek BJ, Berger SL. Chromatin dynamics during herpes simplex virus-1lytic infection. Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):223-7. doi:10.1016/j.bbagrm.2010.01.012. Epub 2010 Feb 6. PMID: 20139038.

Huang J, Dorsey J, Chuikov S, Zhang X, Jenuwein T, Reinberg D, Berger SL.G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem. 2010Mar 26;285(13):9636-9641. doi: 10.1074/jbc.M109.062588. Epub 2010 Jan 29.Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122. Pérez-Burgos, Laura [added].PMID: 20118233; PMCID: PMC2843213.

2009

Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, Johnson FB.Inactivation of the Sas2 histone acetyltransferase delays senescence driven bytelomere dysfunction. EMBO J. 2010 Jan 6;29(1):158-70. doi:10.1038/emboj.2009.314. Epub 2009 Oct 29. PMID: 19875981; PMCID: PMC2808364.

Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL,Howitz K, Marmorstein R. Identification and characterization of novel sirtuininhibitor scaffolds. Bioorg Med Chem. 2009 Oct 1;17(19):7031-41. doi:10.1016/j.bmc.2009.07.073. Epub 2009 Aug 3. PMID: 19734050; PMCID: PMC2929362.

Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A,Kaeberlein M, Kennedy BK, Berger SL. Histone H4 lysine 16 acetylation regulatescellular lifespan. Nature. 2009 Jun 11;459(7248):802-7. doi:10.1038/nature08085. PMID: 19516333; PMCID: PMC2702157.

Govin J, Berger SL. Genome reprogramming during sporulation. Int J DevBiol. 2009;53(2-3):425-32. doi: 10.1387/ijdb.082687jg. PMID: 19412896; PMCID:PMC4039182.

Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An operationaldefinition of epigenetics. Genes Dev. 2009 Apr 1;23(7):781-3. doi:10.1101/gad.1787609. PMID: 19339683; PMCID: PMC3959995.

Lin YY, Lu JY, Zhang J, Walter W, Dang W, Wan J, Tao SC, Qian J, Zhao Y,Boeke JD, Berger SL, Zhu H. Protein acetylation microarray reveals that NuA4controls key metabolic target regulating gluconeogenesis. Cell. 2009 Mar20;136(6):1073-84. doi: 10.1016/j.cell.2009.01.033. PMID: 19303850; PMCID:PMC2696288.

2008

Berger SL. Out of the jaws of death: PRMT5 steers p53. Nat Cell Biol. 2008Dec;10(12):1389-90. doi: 10.1038/ncb1208-1389. PMID: 19043433; PMCID:PMC3922054.

Placek BJ, Huang J, Kent JR, Dorsey J, Rice L, Fraser NW, Berger SL. Thehistone variant H3.3 regulates gene expression during lytic infection withherpes simplex virus type 1. J Virol. 2009 Feb;83(3):1416-21. doi:10.1128/JVI.01276-08. Epub 2008 Nov 12. PMID: 19004946; PMCID: PMC2620911.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N,Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y,Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M. Corrigendum: The histoneH2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressorthrough selective regulation of gene expression. Genes Dev. 2017 Sep15;31(18):1926. doi: 10.1101/gad.307207.117. Erratum for: Genes Dev. 2008 Oct1;22(19):2664-76. PMID: 29051390; PMCID: PMC5695091.

Zediak VP, Berger SL. Hit and run: transient deubiquitylase activity in achromatin-remodeling complex. Mol Cell. 2008 Sep 26;31(6):773-4. doi:10.1016/j.molcel.2008.09.005. PMID: 18922460; PMCID: PMC3922055.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N,Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y,Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M. The histone H2B-specificubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor throughselective regulation of gene expression. Genes Dev. 2008 Oct 1;22(19):2664-76.doi: 10.1101/gad.1703008. Erratum in: Genes Dev. 2017 Sep 15;31(18):1926. PMID:18832071; PMCID: PMC2559905.

Huang J, Berger SL. The emerging field of dynamic lysine methylation ofnon-histone proteins. Curr Opin Genet Dev. 2008 Apr;18(2):152-8. doi:10.1016/j.gde.2008.01.012. Epub 2008 Mar 12. PMID: 18339539.

Walter W, Clynes D, Tang Y, Marmorstein R, Mellor J, Berger SL. 14-3-3interaction with histone H3 involves a dual modification pattern ofphosphoacetylation. Mol Cell Biol. 2008 Apr;28(8):2840-9. doi:10.1128/MCB.01457-07. Epub 2008 Feb 11. PMID: 18268010; PMCID: PMC2293105.

2007

Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, ThorneAW, Berger SL, McMahon SB. The putative cancer stem cell marker USP22 is asubunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell. 2008 Jan 18;29(1):102-11. doi:10.1016/j.molcel.2007.12.015. PMID: 18206973; PMCID: PMC2254522.

Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L,Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y. Newnomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16;131(4):633-6.doi: 10.1016/j.cell.2007.10.039. PMID: 18022353.

Ingvarsdottir K, Edwards C, Lee MG, Lee JS, Schultz DC, Shilatifard A,Shiekhattar R, Berger SL. Histone H3 K4 demethylation during activation andattenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol.2007 Nov;27(22):7856-64. doi: 10.1128/MCB.00801-07. Epub 2007 Sep 17. PMID:17875926; PMCID: PMC2169161.

Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S,Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. p53 is regulated by the lysinedemethylase LSD1. Nature. 2007 Sep 6;449(7158):105-8. doi: 10.1038/nature06092.PMID: 17805299.

Wyce A, Xiao T, Whelan KA, Kosman C, Walter W, Eick D, Hughes TR, KroganNJ, Strahl BD, Berger SL. H2B ubiquitylation acts as a barrier to Ctk1nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex.Mol Cell. 2007 Jul 20;27(2):275-88. doi: 10.1016/j.molcel.2007.01.035. PMID:17643376.

Berger SL. The complex language of chromatin regulation duringtranscription. Nature. 2007 May 24;447(7143):407-12. doi: 10.1038/nature05915.PMID: 17522673.

Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, SchuldinerM, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B,Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A,Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. Functionaldissection of protein complexes involved in yeast chromosome biology using agenetic interaction map. Nature. 2007 Apr 12;446(7137):806-10. doi:10.1038/nature05649. Epub 2007 Feb 21. PMID: 17314980.

Chen Q, Lin L, Smith S, Huang J, Berger SL, Zhou J. CTCF-dependentchromatin boundary element between the latency-associated transcript and ICP0promoters in the herpes simplex virus type 1 genome. J Virol. 2007May;81(10):5192-201. doi: 10.1128/JVI.02447-06. Epub 2007 Jan 31. PMID:17267480; PMCID: PMC1900208.

2006

Zeng PY, Vakoc CR, Chen ZC, Blobel GA, Berger SL. In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatinimmunoprecipitation. Biotechniques. 2006 Dec;41(6):694, 696, 698. doi:10.2144/000112297. PMID: 17191611.

Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA,Kubicek S, Opravil S, Jenuwein T, Berger SL. Repression of p53 activity bySmyd2-mediated methylation. Nature. 2006 Nov 30;444(7119):629-32. doi:10.1038/nature05287. Epub 2006 Nov 15. PMID: 17108971.

Zeng PY, Berger SL. LKB1 is recruited to the p21/WAF1 promoter by p53 tomediate transcriptional activation. Cancer Res. 2006 Nov 15;66(22):10701-8. doi:10.1158/0008-5472.CAN-06-0999. PMID: 17108107.

Huey ED, Grafman J, Wassermann EM, Pietrini P, Tierney MC, Ghetti B, SpinaS, Baker M, Hutton M, Elder JW, Berger SL, Heflin KA, Hardy J, Momeni P.Characteristics of frontotemporal dementia patients with a Progranulin mutation.Ann Neurol. 2006 Sep;60(3):374-80. doi: 10.1002/ana.20969. PMID: 16983677;PMCID: PMC2987739.

Krishnamoorthy T, Chen X, Govin J, Cheung WL, Dorsey J, Schindler K, WinterE, Allis CD, Guacci V, Khochbin S, Fuller MT, Berger SL. Phosphorylation ofhistone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mousespermatogenesis. Genes Dev. 2006 Sep 15;20(18):2580-92. doi:10.1101/gad.1457006. PMID: 16980586; PMCID: PMC1578680.

Vermeulen M, Walter W, Le Guezennec X, Kim J, Edayathumangalam RS, LasonderE, Luger K, Roeder RG, Logie C, Berger SL, Stunnenberg HG. A feed-forwardrepression mechanism anchors the Sin3/histone deacetylase and N-CoR/SMRTcorepressors on chromatin. Mol Cell Biol. 2006 Jul;26(14):5226-36. doi:10.1128/MCB.00440-06. PMID: 16809761; PMCID: PMC1592717.

Huang J, Kent JR, Placek B, Whelan KA, Hollow CM, Zeng PY, Fraser NW,Berger SL. Trimethylation of histone H3 lysine 4 by Set1 in the lytic infectionof human herpes simplex virus 1. J Virol. 2006 Jun;80(12):5740-6. doi:10.1128/JVI.00169-06. PMID: 16731913; PMCID: PMC1472580.

Nathan D, Ingvarsdottir K, Sterner DE, Bylebyl GR, Dokmanovic M, Dorsey JA,Whelan KA, Krsmanovic M, Lane WS, Meluh PB, Johnson ES, Berger SL. Histonesumoylation is a negative regulator in Saccharomyces cerevisiae and showsdynamic interplay with positive-acting histone modifications. Genes Dev. 2006Apr 15;20(8):966-76. doi: 10.1101/gad.1404206. Epub 2006 Apr 5. PMID: 16598039;PMCID: PMC1472304.

Emre NC, Berger SL. Histone post-translational modifications regulatetranscription and silent chromatin in Saccharomyces cerevisiae. Ernst ScheringRes Found Workshop. 2006;(57):127-53. doi: 10.1007/3-540-37633-x_8. PMID:16568953.

Nayak V, Zhao K, Wyce A, Schwartz MF, Lo WS, Berger SL, Marmorstein R.Structure and dimerization of the kinase domain from yeast Snf1, a member of theSnf1/AMPK protein family. Structure. 2006 Mar;14(3):477-85. doi:10.1016/j.str.2005.12.008. PMID: 16531232.

Sterner DE, Nathan D, Reindle A, Johnson ES, Berger SL. Sumoylation of theyeast Gcn5 protein. Biochemistry. 2006 Jan 24;45(3):1035-42. doi:10.1021/bi051624q. PMID: 16411780.

2005

Cheung WL, Turner FB, Krishnamoorthy T, Wolner B, Ahn SH, Foley M, DorseyJA, Peterson CL, Berger SL, Allis CD. Phosphorylation of histone H4 serine 1during DNA damage requires casein kinase II in S. cerevisiae. Curr Biol. 2005Apr 12;15(7):656-60. doi: 10.1016/j.cub.2005.02.049. PMID: 15823538.

Emre NC, Ingvarsdottir K, Wyce A, Wood A, Krogan NJ, Henry KW, Li K,Marmorstein R, Greenblatt JF, Shilatifard A, Berger SL. Maintenance of lowhistone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2association and gene silencing. Mol Cell. 2005 Feb 18;17(4):585-94. doi:10.1016/j.molcel.2005.01.007. PMID: 15721261.

Lo WS, Gamache ER, Henry KW, Yang D, Pillus L, Berger SL. Histone H3phosphorylation can promote TBP recruitment through distinct promoter-specificmechanisms. EMBO J. 2005 Mar 9;24(5):997-1008. doi: 10.1038/sj.emboj.7600577.Epub 2005 Feb 17. PMID: 15719021; PMCID: PMC554127.

Ingvarsdottir K, Krogan NJ, Emre NC, Wyce A, Thompson NJ, Emili A, HughesTR, Greenblatt JF, Berger SL. H2B ubiquitin protease Ubp8 and Sgf11 constitute adiscrete functional module within the Saccharomyces cerevisiae SAGA complex. MolCell Biol. 2005 Feb;25(3):1162-72. doi: 10.1128/MCB.25.3.1162-1172.2005. PMID:15657441; PMCID: PMC544016.

2004

Emre NC, Berger SL. Histone H2B ubiquitylation and deubiquitylation ingenomic regulation. Cold Spring Harb Symp Quant Biol. 2004;69:289-99. doi:10.1101/sqb.2004.69.289. PMID: 16117661.

Zhou J, Berger SL. Good fences make good neighbors: barrier elements andgenomic regulation. Mol Cell. 2004 Nov 19;16(4):500-2. doi:10.1016/j.molcel.2004.11.005. PMID: 15546609.

Kent JR, Zeng PY, Atanasiu D, Gardner J, Fraser NW, Berger SL. During lyticinfection herpes simplex virus type 1 is associated with histones bearingmodifications that correlate with active transcription. J Virol. 2004Sep;78(18):10178-86. doi: 10.1128/JVI.78.18.10178-10186.2004. PMID: 15331750;PMCID: PMC514973.

Wyce A, Henry KW, Berger SL. H2B ubiquitylation and de-ubiquitylation ingene activation. Novartis Found Symp. 2004;259:63-73; discussion 73-7, 163-9.PMID: 15171247.

Lo WS, Henry KW, Schwartz MF, Berger SL. Histone modification patternsduring gene activation. Methods Enzymol. 2004;377:130-53. doi:10.1016/S0076-6879(03)77007-4. PMID: 14979022.

Hiroi H, Christenson LK, Chang L, Sammel MD, Berger SL, Strauss JF 3rd.Temporal and spatial changes in transcription factor binding and histonemodifications at the steroidogenic acute regulatory protein (stAR) locusassociated with stAR transcription. Mol Endocrinol. 2004 Apr;18(4):791-806. doi:10.1210/me.2003-0305. Epub 2004 Jan 15. PMID: 14726488.

2003

Nathan D, Sterner DE, Berger SL. Histone modifications: Now summoningsumoylation. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13118-20. doi:10.1073/pnas.2436173100. Epub 2003 Nov 3. PMID: 14597707; PMCID: PMC263724.

Henry KW, Wyce A, Lo WS, Duggan LJ, Emre NC, Kao CF, Pillus L, ShilatifardA, Osley MA, Berger SL. Transcriptional activation via sequential histone H2Bubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. GenesDev. 2003 Nov 1;17(21):2648-63. doi: 10.1101/gad.1144003. Epub 2003 Oct 16.PMID: 14563679; PMCID: PMC280615.

Clements A, Poux AN, Lo WS, Pillus L, Berger SL, Marmorstein R. Structuralbasis for histone and phosphohistone binding by the GCN5 histoneacetyltransferase. Mol Cell. 2003 Aug;12(2):461-73. doi:10.1016/s1097-2765(03)00288-0. PMID: 14536085.

Barlev NA, Emelyanov AV, Castagnino P, Zegerman P, Bannister AJ, SepulvedaMA, Robert F, Tora L, Kouzarides T, Birshtein BK, Berger SL. A novel human Ada2homologue functions with Gcn5 or Brg1 to coactivate transcription. Mol CellBiol. 2003 Oct;23(19):6944-57. doi: 10.1128/mcb.23.19.6944-6957.2003. PMID:12972612; PMCID: PMC193946.

Cook RF, Cook SJ, Berger SL, Leroux C, Ghabrial NN, Gantz M, Bolin PS,Mousel MR, Montelaro RC, Issel CJ. Enhancement of equine infectious anemia virusvirulence by identification and removal of suboptimal nucleotides. Virology.2003 Sep 1;313(2):588-603. doi: 10.1016/s0042-6822(03)00351-9. PMID: 12954224.

Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA,Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ,Lee YC, Lee JW. Activating signal cointegrator 2 belongs to a novel steady-statecomplex that contains a subset of trithorax group proteins. Mol Cell Biol. 2003Jan;23(1):140-9. doi: 10.1128/mcb.23.1.140-149.2003. PMID: 12482968; PMCID:PMC140670.

2002

Sterner DE, Belotserkovskaya R, Berger SL. SALSA, a variant of yeast SAGA,contains truncated Spt7, which correlates with activated transcription. ProcNatl Acad Sci U S A. 2002 Sep 3;99(18):11622-7. doi: 10.1073/pnas.182021199.Epub 2002 Aug 19. PMID: 12186975; PMCID: PMC129319.

Henry KW, Berger SL. Trans-tail histone modifications: wedge or bridge? NatStruct Biol. 2002 Aug;9(8):565-6. doi: 10.1038/nsb0802-565. PMID: 12145643.

Zhou W, Cook RF, Cook SJ, Hammond SA, Rushlow K, Ghabrial NN, Berger SL,Montelaro RC, Issel CJ. Multiple RNA splicing and the presence of cryptic RNAsplice donor and acceptor sites may contribute to low expression levels and poorimmunogenicity of potential DNA vaccines containing the env gene of equineinfectious anemia virus (EIAV). Vet Microbiol. 2002 Aug 25;88(2):127-51. doi:10.1016/s0378-1135(02)00099-8. PMID: 12135633.

Berger SL. Histone modifications in transcriptional regulation. Curr OpinGenet Dev. 2002 Apr;12(2):142-8. doi: 10.1016/s0959-437x(02)00279-4. PMID:11893486.

Sterner DE, Wang X, Bloom MH, Simon GM, Berger SL. The SANT domain of Ada2is required for normal acetylation of histones by the yeast SAGA complex. J BiolChem. 2002 Mar 8;277(10):8178-86. doi: 10.1074/jbc.M108601200. Epub 2002 Jan 2.PMID: 11777910.

2001

Barlev NA, Liu L, Chehab NH, Mansfield K, Harris KG, Halazonetis TD, BergerSL. Acetylation of p53 activates transcription through recruitment ofcoactivators/histone acetyltransferases. Mol Cell. 2001 Dec;8(6):1243-54. doi:10.1016/s1097-2765(01)00414-2. PMID: 11779500.

Tsavachidou D, Podrzucki W, Seykora J, Berger SL. Gene array analysisreveals changes in peripheral nervous system gene expression following stimulithat result in reactivation of latent herpes simplex virus type 1: induction oftranscription factor Bcl-3. J Virol. 2001 Oct;75(20):9909-17. doi:10.1128/JVI.75.20.9909-9917.2001. PMID: 11559823; PMCID: PMC114562.

Berger SL, Felsenfeld G. Chromatin goes global. Mol Cell. 2001Aug;8(2):263-8. doi: 10.1016/s1097-2765(01)00330-6. PMID: 11545729.

Lo WS, Duggan L, Emre NC, Belotserkovskya R, Lane WS, Shiekhattar R, BergerSL. Snf1–a histone kinase that works in concert with the histoneacetyltransferase Gcn5 to regulate transcription. Science. 2001 Aug10;293(5532):1142-6. doi: 10.1126/science.1062322. PMID: 11498592.

Marmorstein R, Berger SL. Structure and function of bromodomains inchromatin-regulating complexes. Gene. 2001 Jul 11;272(1-2):1-9. doi:10.1016/s0378-1119(01)00519-4. PMID: 11470504.

Berger SL. An embarrassment of niches: the many covalent modifications ofhistones in transcriptional regulation. Oncogene. 2001 May 28;20(24):3007-13.doi: 10.1038/sj.onc.1204324. PMID: 11420715.

Berger SL. Molecular biology. The histone modification circus. Science.2001 Apr 6;292(5514):64-5. PMID: 11294220.

Berger SL. Gene modification with hapaxoterministic restriction enzymes.Easing the way. Methods Mol Biol. 2001;160:443-58. doi:10.1385/1-59259-233-3:443. PMID: 11265302.

2000

Yan Y, Barlev NA, Haley RH, Berger SL, Marmorstein R. Crystal structure ofyeast Esa1 suggests a unified mechanism for catalysis and substrate binding byhistone acetyltransferases. Mol Cell. 2000 Nov;6(5):1195-205. doi:10.1016/s1097-2765(00)00116-7. PMID: 11106757.

Berger SL. Gene regulation. Local or global? Nature. 2000 Nov23;408(6811):412-3, 415. doi: 10.1038/35044160. PMID: 11100706.

Trumbore MW, Berger SL. Prothymosin alpha is a nonspecific facilitator ofnuclear processes: studies of run-on transcription. Protein Expr Purif. 2000Dec;20(3):414-20. doi: 10.1006/prep.2000.1332. PMID: 11087681.

Enkemann SA, Ward RD, Berger SL. Mobility within the nucleus andneighboring cytosol is a key feature of prothymosin-alpha. J Histochem Cytochem.2000 Oct;48(10):1341-55. doi: 10.1177/002215540004801005. PMID: 10990488.

Lo WS, Trievel RC, Rojas JR, Duggan L, Hsu JY, Allis CD, Marmorstein R,Berger SL. Phosphorylation of serine 10 in histone H3 is functionally linked invitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell. 2000Jun;5(6):917-26. doi: 10.1016/s1097-2765(00)80257-9. PMID: 10911986.

Sterner DE, Berger SL. Acetylation of histones and transcription-relatedfactors. Microbiol Mol Biol Rev. 2000 Jun;64(2):435-59. doi:10.1128/mmbr.64.2.435-459.2000. PMID: 10839822; PMCID: PMC98999.

Anafi M, Yang YF, Barlev NA, Govindan MV, Berger SL, Butt TR, Walfish PG.GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1coactivator-dependent gene activation by the human thyroid hormone receptor. MolEndocrinol. 2000 May;14(5):718-32. doi: 10.1210/mend.14.5.0457. PMID: 10809234.

Grant PA, Berger SL, Workman JL. Identification and analysis of nativenucleosomal histone acetyltransferase complexes. Methods Mol Biol.1999;119:311-7. doi: 10.1385/1-59259-681-9:311. PMID: 10804521.

Belotserkovskaya R, Berger SL. Interplay between chromatin modifying andremodeling complexes in transcriptional regulation. Crit Rev Eukaryot Gene Expr.1999;9(3-4):221-30. doi: 10.1615/critreveukargeneexpr.v9.i3-4.70. PMID:10651239.

Enkemann SA, Wang RH, Trumbore MW, Berger SL. Functional discontinuities inprothymosin alpha caused by caspase cleavage in apoptotic cells. J Cell Physiol.2000 Feb;182(2):256-68. doi: 10.1002/(SICI)1097-4652(200002)182:2<256::AID- JCP15>3.0.CO;2-N. PMID: 10623890.

Belotserkovskaya R, Sterner DE, Deng M, Sayre MH, Lieberman PM, Berger SL.Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 atGcn4-activated promoters. Mol Cell Biol. 2000 Jan;20(2):634-47. doi:10.1128/mcb.20.2.634-647.2000. PMID: 10611242; PMCID: PMC85153.

1999

Eberharter A, Sterner DE, Schieltz D, Hassan A, Yates JR 3rd, Berger SL,Workman JL. The ADA complex is a distinct histone acetyltransferase complex inSaccharomyces cerevisiae. Mol Cell Biol. 1999 Oct;19(10):6621-31. doi:10.1128/mcb.19.10.6621. PMID: 10490601; PMCID: PMC84637.

Rojas JR, Trievel RC, Zhou J, Mo Y, Li X, Berger SL, Allis CD, MarmorsteinR. Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide.Nature. 1999 Sep 2;401(6748):93-8. doi: 10.1038/43487. PMID: 10485713.

Massari ME, Grant PA, Pray-Grant MG, Berger SL, Workman JL, Murre C. Aconserved motif present in a class of helix-loop-helix proteins activatestranscription by direct recruitment of the SAGA complex. Mol Cell. 1999Jul;4(1):63-73. doi: 10.1016/s1097-2765(00)80188-4. PMID: 10445028.

Grant PA, Berger SL. Histone acetyltransferase complexes. Semin Cell DevBiol. 1999 Apr;10(2):169-77. doi: 10.1006/scdb.1999.0298. PMID: 10441070.

Trievel RC, Rojas JR, Sterner DE, Venkataramani RN, Wang L, Zhou J, AllisCD, Berger SL, Marmorstein R. Crystal structure and mechanism of histoneacetylation of the yeast GCN5 transcriptional coactivator. Proc Natl Acad Sci US A. 1999 Aug 3;96(16):8931-6. doi: 10.1073/pnas.96.16.8931. PMID: 10430873;PMCID: PMC17710.

Berger SL. Gene activation by histone and factor acetyltransferases. CurrOpin Cell Biol. 1999 Jun;11(3):336-41. doi: 10.1016/S0955-0674(99)80046-5. PMID:10395565.

Clements A, Rojas JR, Trievel RC, Wang L, Berger SL, Marmorstein R. Crystalstructure of the histone acetyltransferase domain of the human PCAFtranscriptional regulator bound to coenzyme A. EMBO J. 1999 Jul1;18(13):3521-32. doi: 10.1093/emboj/18.13.3521. PMID: 10393169; PMCID:PMC1171431.

Enkemann SA, Pavur KS, Ryazanov AG, Berger SL. Does prothymosin alphaaffect the phosphorylation of elongation factor 2? J Biol Chem. 1999 Jun25;274(26):18644-50. doi: 10.1074/jbc.274.26.18644. PMID: 10373476.

Tanner KG, Trievel RC, Kuo MH, Howard RM, Berger SL, Allis CD, MarmorsteinR, Denu JM. Catalytic mechanism and function of invariant glutamic acid 173 fromthe histone acetyltransferase GCN5 transcriptional coactivator. J Biol Chem.1999 Jun 25;274(26):18157-60. doi: 10.1074/jbc.274.26.18157. PMID: 10373413.

Barlev NA, Workman JL, Berger SL. Analysis of activity and regulation ofhGcn5, a human histone acetyltransferase. Methods Enzymol. 1999;304:696-715.doi: 10.1016/s0076-6879(99)04042-2. PMID: 10372391.

Tao L, Wang RH, Enkemann SA, Trumbore MW, Berger SL. Metabolic regulationof protein-bound glutamyl phosphates: insights into the function of prothymosinalpha. J Cell Physiol. 1999 Feb;178(2):154-63. doi:10.1002/(SICI)1097-4652(199902)178:2<154::AID-JCP4>3.0.CO;2-V. PMID: 10048579.

Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD,Berger SL. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivoin response to DNA damage. Mol Cell Biol. 1999 Feb;19(2):1202-9. doi:10.1128/mcb.19.2.1202. PMID: 9891054; PMCID: PMC116049.

Sterner DE, Grant PA, Roberts SM, Duggan LJ, Belotserkovskaya R, PacellaLA, Winston F, Workman JL, Berger SL. Functional organization of the yeast SAGAcomplex: distinct components involved in structural integrity, nucleosomeacetylation, and TATA-binding protein interaction. Mol Cell Biol. 1999Jan;19(1):86-98. doi: 10.1128/mcb.19.1.86. PMID: 9858534; PMCID: PMC83868.

1998

Grant PA, Sterner DE, Duggan LJ, Workman JL, Berger SL. The SAGA unfolds:convergence of transcription regulators in chromatin-modifying complexes. TrendsCell Biol. 1998 May;8(5):193-7. doi: 10.1016/s0962-8924(98)01263-x. PMID:9695838.

Trumbore MW, Manrow RE, Berger SL. Prothymosin alpha is not found in yeast.Protein Expr Purif. 1998 Aug;13(3):383-8. doi: 10.1006/prep.1998.0909. PMID:9693063.

Gregory PD, Schmid A, Zavari M, Lui L, Berger SL, Hörz W. Absence of Gcn5HAT activity defines a novel state in the opening of chromatin at the PHO5promoter in yeast. Mol Cell. 1998 Mar;1(4):495-505. doi:10.1016/s1097-2765(00)80050-7. PMID: 9660934.

Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, Nakatani Y,Allis CD. Cloning of Drosophila GCN5: conserved features among metazoan GCN5family members. Nucleic Acids Res. 1998 Jun 15;26(12):2948-54. doi:10.1093/nar/26.12.2948. PMID: 9611240; PMCID: PMC147644.

Wang L, Liu L, Berger SL. Critical residues for histone acetylation byGcn5, functioning in Ada and SAGA complexes, are also required fortranscriptional function in vivo. Genes Dev. 1998 Mar 1;12(5):640-53. doi:10.1101/gad.12.5.640. PMID: 9499400; PMCID: PMC316586.

Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM,Tommerup N, Vissing H, Sekido Y, Minna J, Borodovsky A, Schultz DC, WilkinsonKD, Maul GG, Barlev N, Berger SL, Prendergast GC, Rauscher FJ 3rd. BAP1: a novelubiquitin hydrolase which binds to the BRCA1 RING finger and enhancesBRCA1-mediated cell growth suppression. Oncogene. 1998 Mar 5;16(9):1097-112.doi: 10.1038/sj.onc.1201861. PMID: 9528852.

Berger SL, King VL. The fluctuation of tear production in the dog. J AmAnim Hosp Assoc. 1998 Jan-Feb;34(1):79-83. doi: 10.5326/15473317-34-1-79. PMID:9527434.

Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, BergerSL. Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinasecomplex. Mol Cell Biol. 1998 Mar;18(3):1349-58. doi: 10.1128/mcb.18.3.1349.PMID: 9488450; PMCID: PMC108848.

Li R, Yu DS, Tanaka M, Zheng L, Berger SL, Stillman B. Activation ofchromosomal DNA replication in Saccharomyces cerevisiae by acidictranscriptional activation domains. Mol Cell Biol. 1998 Mar;18(3):1296-302. doi:10.1128/mcb.18.3.1296. PMID: 9488444; PMCID: PMC108842.

Cook RF, Leroux C, Cook SJ, Berger SL, Lichtenstein DL, Ghabrial NN,Montelaro RC, Issel CJ. Development and characterization of an in vivopathogenic molecular clone of equine infectious anemia virus. J Virol. 1998Feb;72(2):1383-93. doi: 10.1128/JVI.72.2.1383-1393.1998. PMID: 9445039; PMCID:PMC124617.

Tal-Singer R, Podrzucki W, Lasner TM, Skokotas A, Leary JJ, Fraser NW,Berger SL. Use of differential display reverse transcription-PCR to revealcellular changes during stimuli that result in herpes simplex virus type 1reactivation from latency: upregulation of immediate-early cellular responsegenes TIS7, interferon, and interferon regulatory factor-1. J Virol. 1998Feb;72(2):1252-61. doi: 10.1128/JVI.72.2.1252-1261.1998. PMID: 9445025; PMCID:PMC124603.

1997

Wang RH, Tao L, Trumbore MW, Berger SL. Turnover of the acyl phosphates ofhuman and murine prothymosin alpha in vivo. J Biol Chem. 1997 Oct17;272(42):26405-12. doi: 10.1074/jbc.272.42.26405. PMID: 9334215.

Trumbore MW, Wang RH, Enkemann SA, Berger SL. Prothymosin alpha in vivocontains phosphorylated glutamic acid residues. J Biol Chem. 1997 Oct17;272(42):26394-404. doi: 10.1074/jbc.272.42.26394. PMID: 9334214.

Scolnick DM, Chehab NH, Stavridi ES, Lien MC, Caruso L, Moran E, Berger SL,Halazonetis TD. CREB-binding protein and p300/CBP-associated factor aretranscriptional coactivators of the p53 tumor suppressor protein. Cancer Res.1997 Sep 1;57(17):3693-6. PMID: 9288775.

Candau R, Scolnick DM, Darpino P, Ying CY, Halazonetis TD, Berger SL. Twotandem and independent sub-activation domains in the amino terminus of p53require the adaptor complex for activity. Oncogene. 1997 Aug 14;15(7):807-16.doi: 10.1038/sj.onc.1201244. PMID: 9266967.

Grant PA, Duggan L, Côté J, Roberts SM, Brownell JE, Candau R, Ohba R,Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL. Yeast Gcn5 functionsin two multisubunit complexes to acetylate nucleosomal histones:characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev.1997 Jul 1;11(13):1640-50. doi: 10.1101/gad.11.13.1640. PMID: 9224714.

Tal-Singer R, Lasner TM, Podrzucki W, Skokotas A, Leary JJ, Berger SL,Fraser NW. Gene expression during reactivation of herpes simplex virus type 1from latency in the peripheral nervous system is different from that duringlytic infection of tissue cultures. J Virol. 1997 Jul;71(7):5268-76. doi:10.1128/JVI.71.7.5268-5276.1997. PMID: 9188595; PMCID: PMC191763.

1996

Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA. The humantranscriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome17q12-q21 and display a similar tissue expression pattern. Genomics. 1997 Mar15;40(3):497-500. doi: 10.1006/geno.1996.4605. PMID: 9073520.

Candau R, Zhou JX, Allis CD, Berger SL. Histone acetyltransferase activityand interaction with ADA2 are critical for GCN5 function in vivo. EMBO J. 1997Feb 3;16(3):555-65. doi: 10.1093/emboj/16.3.555. PMID: 9034338; PMCID:PMC1169659.

Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, BergerSL. Histone acetyltransferase activity is conserved between yeast and human GCN5and is required for complementation of growth and transcriptional activation.Mol Cell Biol. 1997 Jan;17(1):519-27. doi: 10.1128/mcb.17.1.519. PMID: 8972232;PMCID: PMC231776.

Mizzen CA, Yang XJ, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T,Workman J, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD. The TAF(II)250subunit of TFIID has histone acetyltransferase activity. Cell. 1996 Dec27;87(7):1261-70. doi: 10.1016/s0092-8674(00)81821-8. PMID: 8980232.

Candau R, Berger SL. Structural and functional analysis of yeast putativeadaptors. Evidence for an adaptor complex in vivo. J Biol Chem. 1996 Mar1;271(9):5237-45. doi: 10.1074/jbc.271.9.5237. PMID: 8617808.

Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL.Identification of human proteins functionally conserved with the yeast putativeadaptors ADA2 and GCN5. Mol Cell Biol. 1996 Feb;16(2):593-602. doi:10.1128/mcb.16.2.593. PMID: 8552087; PMCID: PMC231038.

1995

Mol PC, Wang RH, Batey DW, Lee LA, Dang CV, Berger SL. Do products of themyc proto-oncogene play a role in transcriptional regulation of the prothymosinalpha gene? Mol Cell Biol. 1995 Dec;15(12):6999-7009. doi:10.1128/mcb.15.12.6999. PMID: 8524267; PMCID: PMC230955.

Barlev NA, Candau R, Wang L, Darpino P, Silverman N, Berger SL.Characterization of physical interactions of the putative transcriptionaladaptor, ADA2, with acidic activation domains and TATA-binding protein. J BiolChem. 1995 Aug 18;270(33):19337-44. doi: 10.1074/jbc.270.33.19337. PMID:7642611.

Wang L, Turcotte B, Guarente L, Berger SL. The acidic transcriptionalactivation domains of herpes virus VP16 and yeast HAP4 have different co-factorrequirements. Gene. 1995 Jun 9;158(2):163-70. doi: 10.1016/0378-1119(95)00126-q.PMID: 7607537.

Berger SL, Scagliotti RH, Lund EM. A quantitative study of the effects ofTribrissen on canine tear production. J Am Anim Hosp Assoc. 1995 May-Jun;31(3):236-41. doi: 10.5326/15473317-31-3-236. PMID: 7634058.

Cook RF, Berger SL, Rushlow KE, McManus JM, Cook SJ, Harrold S, Raabe ML,Montelaro RC, Issel CJ. Enhanced sensitivity to neutralizing antibodies in avariant of equine infectious anemia virus is linked to amino acid substitutionsin the surface unit envelope glycoprotein. J Virol. 1995 Mar;69(3):1493-9. doi:10.1128/JVI.69.3.1493-1499.1995. PMID: 7853482; PMCID: PMC188739.

1994

Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L. Functionalsimilarity and physical association between GCN5 and ADA2: putativetranscriptional adaptors. EMBO J. 1994 Oct 17;13(20):4807-15. PMID: 7957049;PMCID: PMC395419.

Berger SL. Rescue of a failed polymerase chain reaction catalyzed by ventor deep vent DNA polymerase with 10% dimethyl sulfoxide. Anal Biochem. 1994Oct;222(1):290-3. doi: 10.1006/abio.1994.1490. PMID: 7856867.

Berger SL. Expanding the potential of restriction endonucleases: use ofhapaxoterministic enzymes. Anal Biochem. 1994 Oct;222(1):1-8. doi:10.1006/abio.1994.1445. Erratum in: Anal Biochem 1995 Feb 10;225(1):195. PMID:7856834.

Berger SL, Meselson M. Production and cleavage of Drosophila hsp70transcripts extending beyond the polyadenylation site. Nucleic Acids Res. 1994Aug 11;22(15):3218-25. doi: 10.1093/nar/22.15.3218. PMID: 8065938; PMCID:PMC310299.

1993

Manrow RE, Berger SL. GAG triplets as splice acceptors of last resort. Anunusual form of alternative splicing in prothymosin alpha pre-mRNA. J Mol Biol.1993 Nov 20;234(2):281-8. doi: 10.1006/jmbi.1993.1583. PMID: 7901421.

Berger SL, Manrow RE, Lee HY. Phoenix mutagenesis: one-step reassembly ofmultiply cleaved plasmids with mixtures of mutant and wild-type fragments. AnalBiochem. 1993 Nov 1;214(2):571-9. doi: 10.1006/abio.1993.1540. PMID: 7906495.

Sburlati AR, De La Rosa A, Batey DW, Kurys GL, Manrow RE, Pannell LK,Martin BM, Sheeley DM, Berger SL. Phosphorylation of human and bovineprothymosin alpha in vivo. Biochemistry. 1993 May 4;32(17):4587-96. doi:10.1021/bi00068a015. PMID: 8485135.

1992

Berger SL, Piña B, Silverman N, Marcus GA, Agapite J, Regier JL,Triezenberg SJ, Guarente L. Genetic isolation of ADA2: a potentialtranscriptional adaptor required for function of certain acidic activationdomains. Cell. 1992 Jul 24;70(2):251-65. doi: 10.1016/0092-8674(92)90100-q.PMID: 1638630.

Manrow RE, Leone A, Krug MS, Eschenfeldt WH, Berger SL. The humanprothymosin alpha gene family contains several processed pseudogenes lackingdeleterious lesions. Genomics. 1992 Jun;13(2):319-31. doi:10.1016/0888-7543(92)90248-q. PMID: 1612591.

1991

Krug MS, Berger SL. Reverse transcriptase from human immunodeficiencyvirus: a single template-primer binding site serves two physically separablecatalytic functions. Biochemistry. 1991 Nov 5;30(44):10614-23. doi:10.1021/bi00108a003. PMID: 1718423.

Manrow RE, Sburlati AR, Hanover JA, Berger SL. Nuclear targeting ofprothymosin alpha. J Biol Chem. 1991 Feb 25;266(6):3916-24. PMID: 1899869.

Sburlati AR, Manrow RE, Berger SL. Prothymosin alpha antisense oligomersinhibit myeloma cell division. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):253-7.doi: 10.1073/pnas.88.1.253. PMID: 1986372; PMCID: PMC50788.

Berger SL, Palmer RH, Hodges CC, Hall DG. Neurologic manifestations oftrypanosomiasis in a dog. J Am Vet Med Assoc. 1991 Jan 1;198(1):132-4. PMID:1899857.

1990

Sburlati AR, Manrow RE, Berger SL. Human prothymosin alpha: purification ofa highly acidic nuclear protein by means of a phenol extraction. Protein ExprPurif. 1990 Nov;1(2):184-90. doi: 10.1016/1046-5928(90)90014-p. PMID: 2136239.

Berger SL, Cress WD, Cress A, Triezenberg SJ, Guarente L. Selectiveinhibition of activated but not basal transcription by the acidic activationdomain of VP16: evidence for transcriptional adaptors. Cell. 1990 Jun29;61(7):1199-208. doi: 10.1016/0092-8674(90)90684-7. PMID: 2163758.

Previous Next
Close
Test Caption
Test Description goes like this